Genome Modification Technologies
B-5. RNA-Binding PPR Proteins for Organellar Genome Editing
Transcriptome engineering by designer PPR protein
In vivo control of translation and splicing
T. Nakamura, Kyushu Univ.
tnakaagr.kyushu-u.ac.jp
Technical Description
Summary:
We provide “designer RNA binding protein using PPR motifs” and the related application, including splicing and translation, to edit or engineering in vivo RNA, without DNA alternation.
Technical advantages:
- PPR is a versatile RNA engineering technique (patent approved).
- Change of genome function at RNA level with no alternation of genomic DNA
- The technique enables spatiotemporal regulation of essential RNA in vivo
Application Destination
- Engineering of metabolic pathway for production of valuable materials
- Pharmaceutical use targeting aberrant endogenous RNA
- Diagnosis and therapeutic use against RNA virus
Reference Material
- Designer RNA binding protein using PPR motifs (WO/2013/058404)
- Translational control by designer PPR protein (2016-120524)
Contact Information
Takahiro NAKAMURA, Kyushu University
- E-mail:tnakaagr.Kyushu-u.ac.jp
- URL:https://www.kyushu-u.ac.jp/ja/