Genome Modification Technologies
B-2. Precision Genome Design
Precise Genome Engineering by Recombinase
Synthetic recombinases for genome editing
W. Nomura, Hiroshima Univ.
wnomurahiroshima-u.ac.jp
Technical Description
Application Destination
- Needs for large gene fragment insertion, which is not efficient by nuclease-based gene editing.
- Needs for alternate integration methods such as Flp-in® with expanded site options.
Reference Material
- Nomura, W., et al. “Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System.” Biochemistry 51; 1510-1517, 2012.
Contact Information
Graduate School of Biomedical and Health Science, Hiroshima University
- E-mail: wnomurahiroshima-u.ac.jp
- URL: https://nomulab.hiroshima-u.ac.jp/