DNA Recognition Modules
A-2. Development of Novel Genome-Editing Systems Leveraging Evolutionary Engineering and Molecular Dynamics Approaches
Development of a novel genome editing tool by molecular evolution and molecular dynamics approaches
- Development of a novel genome editing tool by molecular evolution engineering -
Tokushima Univ., RIKEN, Meiji Univ., Kinki Univ.; K. Osakabe, Tokushima Univ.
kosakabetokushima-u.ac.jp
Technical Description
Most of basic patents for genome editing has been issued by the United States and Europe. Therefore, it has been strongly desired to develop novel genome editing tools that contribute to the activation of the Japanese biotechnological industry. We developed a novel genome editing system, which has not been utilized for genome editing, from metagenome data. This tool could introduce a site-directed mutation on the target of interest in plants.
Application Destination
- Breeding of metabolically engineered plants and cells for the production of useful chemicals.
- Breeding of varieties of agricultural, forestry, and fishery products with useful traits.
- Application in the fields of medicine and drug discovery.
Reference Material
- Patent application No. WO/2019/039417 “Target sequence specific alteration techniques using nucleotide target recognition.” (Tokushima University)
- Patent application No. PCT/JP2020/11283 “Targeted sequence modification technology using the CRISPR type I-D system.” (Tokushima University)
Contact Information
Keishi Osakabe, Tokushima University
- E-mail: kosakabetokushima-u.ac.jp
- URL: https://www.tokushima-u.ac.jp/english/